Clinical News From Annals Of Internal Medicine

Vitamin D Deficiency Puts Older Women at Risk for Hip Fracture



Previous studies of the effect of low blood vitamin D levels on the risk for hip fractures in older women have given inconsistent results. In this study, researchers took blood to measure vitamin D levels and gathered information about fracture risk from 800 women between the ages of 50 and 79. After following the women for up to nine years, the researchers re-examined them to see who developed hip fractures. The women with hip fractures had lower vitamin D levels - the very lowest of which seemed to increase the risk for hip fractures independently of other factors known to increase hip fracture risk.



Documentary Evidence Reveals Motives of Pharmaceutical "Seeding" Trials



Clinical studies that are designed by pharmaceutical companies to promote use of their drugs are called "seeding" trials. While much has been written about the marketing tactics of the pharmaceutical industry, seeding trials have not been characterized in depth. A new study finds strong documentary evidence of how a pharmaceutical company framed a marketing effort as a clinical trial. Researchers reviewed internal documents that became public during litigation against the drug manufacturer. The company's marketing division designed the trial, and handled all collection, analysis, and dissemination of data. The company hid their motive for the trial from participants, investigators, and institutional review board members. Researchers concluded that seeding trials are harmful for three reasons: First, because the company disguises its motives, informed consent is impossible; second, good quality research is at risk when marketers - rather than scientists - design a study; and third, the scientific question posed by a seeding trial often has little merit. An accompanying editorial warns institutional research review boards to avoid approving seeding trials and physicians to avoid enrolling their patients in them.







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Source: Angela Collom


American College of Physicians